Low Viscosity HPMC Grades Designed For Applications Like Film Coating And Taste Masking. The Lower Viscosity Grades Can Give Films Of Low Tensile Strength While The Higher Viscosity Grades Will Give Higher Film Strength With An Added Benefit Of Sustained Release. Exclusive White Grades Of Pharmacoat Are Devised For Whiter Films And Prolonged Storage Stability There On.
   Shin-Etsu Chemical Co. Ltd. Japan
 Methylcellulose and Hydroxy Propyl Methyl Cellulose Are The Water Soluble Non-Ionic Cellulose Ethers Available In A Wide Range Of Viscosities And Thermal Gelation Temperatures. Highly Purified Natural Pulp Is Etherified With Methyl Chloride Or With The Combination Of Methyl Chloride And Propylene Oxide To Form Water Soluble, Non – Ionic Cellulose Ether. Sustained Release (Control Release) Matrix Formulations With Quick Hydration And Gel Formation Qualities Are Obtained With Metolose SR. Metolose SR Is Manufactured Under Tighter Specification For Substituents. Particle Size Is Controlled To 50µm During Manufacture Which Is Ideal For Matrix Application With Sustained Release. 90 SH Grades Are Typically Labelled As SR Grades Due To Their Substitution Type. Low Substituted Hydroxypropyl Cellulose Is Water Insoluble Disintegrant And Dry Binder For Direct Compression Applications. Average Number Of Hydroxypropoxy Groups Per Glucose Ring Unit Is 0.2 Due To Which It Is Swellable And Insoluble In Water Imparting Hardness, Binding Capability And Better Disintegration To The Tablet Formulations. Hydroxypropyl Methyl Cellulose Phthalate Is A Phthalic Half Ester Of HPMC Exclusively Used As An Solvent Based Enteric Coating Agent In Solid Dosages Due To Its Resistance To Dissolution In Simulated Gastric Fluids. Hydroxypropyl Methyl Cellulose Acetate Succinate Is An Enteric Coating Agent With Multiple Coating Methods And Its Grades Are Obtained When HPMC Is Blended With Acetic Anhydride And Succinic Anhydride. AQOAT Grades Are Differentiated From Each Other Based On Acetyl Content, Succinoyl Content, Partical Size, And Hence The Typical Application. AS-LF, AS-MF, AS-HF Are The Micronised Grades Of 5 µm For Aqueous Enteric Coating While AS-LG, AS-MG, AS-HG Are The Granular Grades Of 1000 µm For Solvent Based Enteric Coating Of Solid Dosages. |
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