:: ARIHANT TRADING Co. ::

Xanthan gum is widely used in oral and topical pharmaceutical formulations, cosmetics, and foods as a suspending and stabilizing agent. It is also used as a thickening and emulsifying agent. It is nontoxic, compatible with most other pharmaceutical ingredients, and has good stability and viscosity properties over a wide pH and temperature range;

Although primarily used as a suspending agent, Xanthan gum has also been used to prepare sustained-release matrix tablets. Controlled-release tablets of diltiazem hydrochloride prepared using xanthan gum have been reported to sustain the drug release in a predictable manner and the drug release profiles of these tablets were not affected by pH and agitation rate.

Citric acid is widely used in pharmaceutical formulations and food products, primarily to adjust the pH of solutions. It has also been used experimentally to adjust the pH of tablet matrices in enteric coated formulations for colon-specific drug delivery. Anhydrous citric acid is widely used in the preparation of effervescent tablets. In food products, citric acid is used as a flavor enhancer for its tart, acidic taste. Citric acid monohydrate is used as a sequestering agent and antioxidant synergist. It is also a component of anticoagulant citrate solutions.

Triethyl citrate and the related esters acetyltriethyl citrate, tributyl citrate, and acetyltributyl are used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads, and granules for taste masking, immediate release, sustainedrelease, and enteric formulations. Triethyl citrate is also used as a direct food additive for flavoring, for solvency, and as a surface active agent.

Trisodium citrate is a tribasic salt of citric acid. It is produced by complete neutralisation of citric acid with high purity sodium hydroxide or carbonate and subsequent crystallisation and dehydration.

The common hydrate form, trisodium citrate dihydrate, is widely used in foods, beverages and various technical applications mainly as buffering, sequestering or emulsifying agent, whereas the anhydrous form finds its uses in particular applications such as water sensitive dry blends and instant beverages, surfactants, fragrances as well as in tablets and OTC products.
Jungbunzlauer trisodium citrate anhydrous is manufactured from trisodium citrate dihydrate. Water molecules of the dihydrate crystals are removed by a patented process without destroying the original crystal matrix. The resulting crystals have a porous matrix that can be used as a carrier for inorganic and/or organic substances, especially after being impregnated with liquids. Further, due to the absence of water, the product is not prone to caking. Trisodium citrate anhydrous is also used in applications where excess water is not desired.