CM-Glucam Granulate

The repair and defense molecule
CM-Glucan Granulate is a derivative of ß-(1,3) and ß-(1,6) glucan, a natural yeast polysaccharide with immune-stimulating properties.

ß-Glucan isolated from yeast is insoluble in water and therefore not suitable for topical use. Thus, Mibelle Biochemistry has developed a process to offer CM-Glucan Granulate, a biologically active ß-glucan derivative which keeps the same biological activity as ß-glucan, is highly purified and water-soluble.

Numerous clinical studies have demonstrated the benefits of CM-Glucan Granulate on either extremely sensitive skin or skin that is exposed to extreme stress such as esthetic procedures.

Claim Ideas for CM-Glucan Granulate
• Increases the skin's self-protecting capacity 
• Accelerates skin recovery
• Restores the skin's moisture barrier

EpiCalmin TCM

EpiCalmin TCM is a synergic combination of 3 plants used in traditional Chinese medicine (TCM). In collaboration with an expert in TCM, Mibelle Biochemistry selected these plants according to their strong soothing activity long known in TCM.

For the first time, Mibelle Biochemistry scientifically demonstrated the mechanism of activity for the specific plant combination in EpiCalmin TCM by gene array analysis and proved its efficacy by in-vivo studies.

Results showed that EpiCalmin TCM effectively reinforces the skin’s self-protection against dehydration, oxidative stress and also degradation of the extra-cellular matrix. Thus EpiCalmin TCM which is ECOCERT approved, actively protects the skin and prevents premature aging.

Claims with EpiCalmin TCM
• Reinforces the skin’s natural defense system
• Actively prevents skin aging
• Improves skin hydration
• Soothes irritation
• Skin feels soft, moisturized and comfortable

Phyto Cell Tec™ Alp Rose

Charges Skin stem cell resistance
Alpine roses are typical Swiss flowers which grow at altitudes of 1500 - 3000 m. In these distinct environments, they must adapt to extreme conditions such as the cold, UV and dryness. PhytoCellTec™ Alp Rose – based on alpine rose stem cells – has captured these characteristics.
PhytoCellTec™ Alp Rose helps to maintain skin stem cells characteristics and to protect these precious cells  against UV-stress.

As a consequence, it ensures improved skin condition by

• increasing skin stem cell vitality
• boosting the epidermal regeneration
• improving skin barrier function
• helping the skin to cope with climate changes

PhytoCellTec™ Alp Rose has been carefully developed to protect the most valuable skin cells, the skin stem cells, against environmental stress factors and to improve their functions.

Phyto Cell Tec™ Malus Domestica

Plant stem cells to protects skin stem cells
PhytoCellTec™ Malus Domestica - the first plant stem cell active for skin stem cell protection with proven efficacy

PhytoCellTec™ Malus Domestica is a liposomal preparation of apple stem cells developed by a novel, patent pending plant cell culture technology.
PhytoCellTec™ - a novel plant cell culture technology has been invented to cultivate dedifferentiated callus cells from a rare Swiss apple. These apple stem cells are rich in epigenetic factors and metabolites, assuring the longevity of skin cells. PhytoCellTec™ Malus Domestica has been shown to protect skin stem cells and delay the senescence of hair follicles.
PhytoCellTec™ Malus Domestica provides a revolutionary anti-aging performance for real rejuvenation.

Claims with PhytoCellTec™ Malus Domestica
• Protects longevity of skin stem cells
• Delays senescence of essential cells
• Combats chronological aging 
• Patent pending
• Award winner (BSB innovation prize for the best active ingredient 2008)

Phyto Cell Tec™ Solar Vitis

protects epidermal stem cells against UV damage

PhytoCellTec™ Solar Vitis is based on stem cells derived from a specific grape cultivar that has been obtained through our unique PhytoCellTec™ technology.
As we all know UV radiation is responsible for 80% of skin aging. Despite the use of sun protection filters, toxins and free radicals are generated by UV in the skin. This affects sensitive cells such as the epidermal stem cells which are essential and most valuable.
The activity of skin stem cells is the key factor in ensuring the vitality and regeneration capacity of the skin. PhytoCellTec™ Solar Vitis both protects and maintains the activity of epidermal stem cells - even in cases of stress induced by UV.

Claims with PhytoCellTecTM Solar Vitis
• Protects skin stem cells against UV stress 
• Delays senescence of essential cells
• Fights photo-aging
• For a vital and healthy-looking skin

Lipobelle Soyaglycone

Lift it  up

Lipobelle Soyaglycone is a liposomal preparation of genistein, the biologically active form of the most abundant soy isoflavone. Genistein is a powerful collagen booster: it strongly simulates the production of collagen but also prevents its degradation by matrix metalloproteinases.
Studies prove that Lipobelle Soyaglycone increases skin thickness (+12% xcompared to placebo) and that it has a lifting effect. Besides, Lipobelle Soyaglycone was shown to make the skin appear 5 years younger due to a reduced appearance of wrinkles.

Claims with Lipobelle Soyaglycone
• Delivers a visible lift
• Reduces lines and wrinkles
• Re-densifies and firms the skin 
• Skin appears 5 years younger 

Lipobelle Soyaglycone

To fade away expression Lines
Ameliox is a powerful combination of carnosine and the milk thistle compound silymarin that stops the formation of wrinkles and fine lines.
Carnosine and silymarin effectively inhibit glycation, the chemical reaction between free sugars and collagen. In skin, glycation is the cause for the stiffening of structural components such as collagen fibres and their subsequent degradation. Carnosine reacts very quickly with free sugars and prevents collagen fibres from being attacked. Silymarin, a polyphenolic substance isolated from milk thistle, is a highly effective antioxidant. Because oxidation is an essential reaction step in the glycation process, silymarin is also an inhibitor of glycation and as a powerful antioxidant it prevents lipid peroxidation.
Claims with Ameliox
• Visibly reduces wrinkles
- 27% crow’s feet area
- 24% frownlines
• Improves firmness
• Rejuvenation by relaxation of skin collagen
• Skin relaxation by reducing stiffening of the collagen fibres

Astraforce

AntiAgeing especially for blemished skin
AstraForce, a liposomal extract of Astragalus membranaceus roots, is an effective anti-aging active especially for blemish-prone, oily or combination skin.
Astragalus membranaceus is one of the most important Chinese medical herbs. Its roots have been used for more than 2500 years in Chinese medicine to strengthen qi, the body's life force. Among its numerous properties, Astragalus membranaceus root extract is capable of enhancing the immune system and the metabolism, notably the micro-circulation.
AstraForce with its double proven activity improves firmness, smoothness and hydration while reducing imperfections, inflammation and sebum flow.

Claims with AstraForce
• Firms and smoothes the skin
• Reduces imperfections
• Balances sebum production
• Helps prevent breakouts
• For a clear and refined skin complexion

MAXnolia

Fights Skin inflamm'aging
MAXnolia is a water-dispersible active powder based on a premium magnolia bark extrakt. Magnolia contains two pharmacologically active components called magnolol and honokiol, which synergistically inhibit inflammatory and aging processes.
MAXnolia thus counteracts chronic inflammation in aging skin.

Claims with MAXnolia
• Protects skin against chronic inflammation
• Neutralizes internal aging factors
• Reduces skin redness

Perfection Peptide P3

Biomimetic Peeling to create a perfect skin
PerfectionPeptide P3 is a liposomal preparation of a tripeptide which activates the regeneration of the skin.
PerfectionPeptide P3 stimulates the natural desquamation process of the skin leading to gentle peeling. Consequently a brighter, smoother and more evenly toned skin complexion is created. The skin is rejuvenated and looks younger.

Studies with PerfectionPeptide P3 show an increase in cell turnover and hydration, improve of skin firmness and reduction of wrinkles.
Claims with PerfectionPeptide P3
• Rejuvenates the skin
• Gentle biomimetic peeling
• Improves smoothness, clarity and radiance
• Reduces fine lines
• Activates skin cell regeneration

Perfection Peptide P3

Phyto-endorphins in a double vector system
Happybelle-PE contains a phyo-endorphin complex based on monk's pepper known for its mood enhancing activity. In combination with antioxidant and moisturizing factors it fights against all signs of aging.
Phyto-endorphins from Happybelle-PE are structurally similar to beta-endorphins, small neuropeptides mainly produced in the brain. In connection with happy moments, the molecules bind to the opioid receptors, causing an analgesic effect and a sense of well-being. New cosmetic science showed that beta-endorphins also play an important role in the vitality and appearance of the skin and make the skin look more radiant.
Thus, Happybelle-PE provides intensive hydration and pure moments of happiness, leaving the skin smooth and luscious. The ultra-penetrating double vector system grants a fast and potent activity of Happybelle-PE.

Claims with Happybelle-PE
• Rejuvenates and moisturizes skin
• Gives a radiant glow
• For pure moments of happiness

Amarashape

High Performance in body shaping
AmaraShape is a highly effective combination of fat burning actives for a topical treatment of thighs, buttocks, hips, waist and arms.
AmaraShape contains the active substances caffeine and Synephrine, a highly active compound isolated from bitter orange (Citrus aurantium).It was first used by body builders as a fat loss stimulant and to increase the metabolic rate. Synephrine and caffeine activate the breakdown of lipids in fat cells of the adipose tissue.
To facilitate the penetration into the skin, caffeine and synephrine are enclosed in liposomes. AmaraShape - for highly performing body shaping products.

Claims with AmaraShape
• Refines body contours
• Firms and tones
• Smoothes ski

Iso-Slim Complex

Pro –Slimming Anti -Cellulite
Iso-SlimComplex is both a slimming and anti-cellulite ingredient based on genistein, the biologically active form of the most abundat soy isoflavone. Genistein is a powerful anti-cellulite ingredient: It inhibits the formation of new adipocytes (cells specialized for fat storage), promotes the fat breakdown and also strongly improves skin strength, firmness and smoothness.

Iso-SlimComplex combines genistein with 3 other active substances: caffeine and carnitine which stimulate the fat breakdown and spirulina platensis with firming and restructuring properties.

Studies showed that Iso-SlimComplex inhibits the differentiation of pre-adipocytes into adipocytes and that the production of collagen IV is stimulated. In-vivo Iso-SlimComplex' extraordinary slimming and anti-cellulite effects were confirmed.

Claims with Iso-SlimComplex
• Visibly reduces cellulite (degree of cellulite -37%)
• Multi-targeted slimming activity (thigh girth -3.8 cm)
• Boosts collagen production for a firmer look

GSP-T

Powerful protection for all hair types and styles
GSP-T is a powerful antioxidant complex which combines water-soluble Swiss grape seed procyanidins and oil-soluble natural tocopherol. GSP-T is transparent, water-soluble and easy to formulate.

Procyanidins are potent antioxidants and free radical scavengers. They are found in high concentrations in Swiss Pinot Noir grapes. Hair is constantly exposed to stresses which damage it and make it more sensitive.

In 6 ex-vivo studies mimicking real-life conditions, GSP-T was shown to protect hair against:
•  Physical stresses (UV, hair-dryer)
•  Chemical stresses (sea water, surfactant).
Besides, GSP-T was shown to protect dyed hair from color fading as well as to reduce, on a short-term basis, the cutaneous irritation induced by alkaline pH.

Claims with GSP-T for Hair
• Shields hair against daily stress factors
• Locks in color, resists fading
• Prevents damage due to heat-styling
• Helps to rebalance the scalp

Nano-Lipobelle DNCoQ10 oA

Supersaturated Coq10 double nanoemulsion
Nano-Lipobelle DN CoQ10 oA is a double nano-emulsion combining coenzyme Q10 with vitamin E and C. Coenzyme Q10 (ubiquinone) is a strong antioxidant able to activate cell metabolism. Together with vitamin C and E, which fight against oxidants in a synergistic way, it offers a high anti-oxidant protection to the skin . Nano-Lipobelle DN CoQ10 oA is a hair growth active by stimulating the proliferation of hair follicle papilla and by protecting mitochondrial DNA.
Nano-Lipobelle DN CoQ10 oA is ideal to fight against scalp and hair aging but also to reinforce and revitalize hair. Transparent active ingredient, paraben- and phenoxyethanol-free.

Claims with Nano-Lipobelle DN CoQ10 oA
• Stimulates hair growth
• Protects against oxidants
• Strengthens and vitalizes hair
• Anti-aging for scalp and hair

AquaCacteen

Soothes and Hydrates Men’s and Women’s Skin
AquaCacteen is an ultra-refined elixir from prickly pear (Opuntia ficus-indica).
AquaCacteen blocks the release of stress markers from sensory nerve cells in the skin and calms and soothes irritated skin. Furthermore, AquaCacteen has excellent hydrating properties due to its high content of water-binding compounds.
Clinical studies conducted on both women and men showed that AquaCacteen was exceptionally soothing and firming. Besides it was found to be very hydrating even in rinse-off products.

Claims with AquaCacteen
• Soothes and calms irritated skin
• Hydrates the skin even in rinse-off formulation
• Protects and firms the skin
Available in an ECOCERT certified version

Trimoist

24H Hydration and Protection
Trimoist with its highly effective moisturizing system supports the 3 elements of the skin‘s own moisture balance system:
1. Film forming polysaccharides protect the skin
2. Lamellar lipids boost the moisture barrier
3. Humectants provide an instant burst of hydration +  Carnosine, a dipeptide to prevent skin aging

Key components of Trimoist
CM-Glucan, Phytosterol, Sodium Stearoyl Lactylate, Oleic Acid Triglyceride

Claims with Trimoist
• 24h hydration
• More than hydration, more than protection, more than anti-aging
• Firmness

Delentigo™

The age spot solution
Delentigo™ is a cosmetic ingredient to fight age spots and to create an even skin tone.
Age spots are characterized by a local overproduction of the two pigments melanin and lipofuscin. Delentigo™ prevents and reduces the synthesis of both these pigments. Compared to classical whitening products, that generally lighten the skin, Delentigo™ has a targeted, stronger lightening effect on age spots than on the surrounding normally pigmented skin. Delentigo™ is based on sulphoraphane from cress sprouts, a "second generation" anti-oxidant and genistein from soy, a natural inhibitor of the tyrosine kinase. Encapsulated in an advanced vector system Delentigo™ allows a targeted and time-releasing activity.

Clinical studies showed that Delentigo™
• creates an even skin tone
• visibly reduces age spots
• prevents photo-aging and dark spots

NanoWhite

Triple Activity for Skin brightening
NanoWhite is a liposomal preparation combining powerful whitening ingredients from bearberries and antioxidants for a strong brightening effect.

Thanks to its specific composition, NanoWhite regulates pigmentation process through complementary pathways:
• Natural arbutin from bearberry strongly inhibits tyrosinase, the key enzyme of the pigmentation process.
• Reduced glutathione and vitamin C palmitate reinforce NanoWhite’s safe and proven activity with their whitening and anti-oxidant properties.
• A liposomal formulation optimises the effectiveness of all these components.

NanoWhite inhibits both the tyrosinase activity and the activation of this enzyme. NanoWhite is thus a safe yet powerful whitening ingredient ideal to reduce and prevent pigmentation disorders.

Claims with NanoWhite
• Safely inhibits the pigmentation process
• Reduces both human tyrosinase activation and activity
• Reduces melanin synthesis
• Fights against pigmentation disorders
• For a luminous even skin tone

SulforaWhite

Phyto agent for visible for Whitening
SulforaWhite is a liposomal preparation of Swiss garden cress sprouts rich in sulforaphane, a powerful whitening antioxidant phytonutrient.
SulforaWhite effectively inhibits pigmentation by targeting the two upstream key reaction steps in the melanin cascade: it neutralizes reactive oxygen species and inhibits the binding of á-MSH, a natural hormone which stimulates skin pigmentation.
SulforaWhite reduces the effects of daytime stressors and helps to prevent the formation of melanin for a brighter, more luminous skin complexion.

Claims with SulforaWhite
• Effectively inhibits melanin formation
• Provides exceptional brightening benefits
• Fades the appearance of age spots and discolorations
• Reduces the effects of daytime stressors
• Evens skin ton

TinyWhite

Activity for skin brightening
Tiny White is an optimal delivery system for the biological extracts and an excellent skin softening agent. The liposomal product contains Natural Arbutin from Bearberry, Grapeseed Extract ,Vitamin F & E along with Glutathione.
Arbutin strongly inhibits tyrosinase activity. Glucathione is one of the skin’s strongest antioxidants that Inhibits the tyrosinase activity, thanks to its reduction potential .GrapeSeed Extract act as antioxidant &  can significantly reduce the formation of melanin since this is an oxidative process.

Claims with Tiny White
 Safely inhibits the pigmentation process
•Anti-oxidant activity
•Reduces melanin synthesis
•For a luminous even skin tone

EpiCalmin TCM

EpiCalmin TCM is a synergic combination of 3 plants used in traditional Chinese medicine (TCM). In collaboration with an expert in TCM, Mibelle Biochemistry selected these plants according to their strong soothing activity long known in TCM.

For the first time, Mibelle Biochemistry scientifically demonstrated the mechanism of activity for the specific plant combination in EpiCalmin TCM by gene array analysis and proved its efficacy by in-vivo studies.

Results showed that EpiCalmin TCM effectively reinforces the skin’s self-protection against dehydration, oxidative stress and also degradation of the extra-cellular matrix. Thus EpiCalmin TCM which is ECOCERT approved, actively protects the skin and prevents premature aging.

Claims with EpiCalmin TCM
• Reinforces the skin’s natural defense system
• Actively prevents skin aging
• Improves skin hydration
• Soothes irritation
• Skin feels soft, moisturized and comfortable

Noriguard nc

Ecocert-approved active ingredient for the prevention of photo-aging
An alga able to protect itself against daily radiation
• Noriguard nc is an extract based on the Porphyra umbilicalis alga also called Nori
• This red alga lives at the shoreline, exposed to extreme solar radiation
• To protect itself from daily UVA radiation, it naturally produces mycosporine-like amino acids (MAA), able to absorb UVA rays
• Porphyra umbilicalis is also used in nutritional supplements because of its exceptional nutrient
composition (high protein content and richness in polyunsaturated fatty acids and vitamins)

Claims
• Prevents skin photo-aging
• Prevents UV-induced damages on the skin

Applications
Day creams, anti-aging prevention, natural & organic products, hand care, hair care, make-up

NanoVit oA/ nc

Bioactive omega 3,6,9 and 7 for skin
Regeneration and Antioxidant Activity
NanoVit is a nano-emulsion loaded with sea buckthornpulp oil. Sea buckthorn is a hardy plant able to resist high and low temperatures, dryness, sand and salt.

Sea buckthorn pulp oil has a unique fatty acid composition:  It contains more than 50 % of unsaturated fatty acids and is exceptionally rich in omega-7 which is rarely found in the plant kingdom.

The encapsulation of sea buckthorn pulp oil in a nano-emulsion increases its penetration and activity while protecting it from deactivation. NanoVit combines antioxidant activity with a regenerative effect. Thus, it can prevent lipid peroxidation while improving the skin metabolism resulting in a healthy-looking skin.

Claims with NanoVit
• Regenerates the skin
• Protects against UV damage
• Antioxidant activity
• For a vital and healthy-looking skin

AquaCacteen nc

Soothes and Hydrates Men’s and Women’s Skin
AquaCacteen is an ultra-refined elixir from prickly pear (Opuntia ficus-indica).
AquaCacteen blocks the release of stress markers from sensory nerve cells in the skin and calms and soothes irritated skin. Furthermore, AquaCacteen has excellent hydrating properties due to its high content of water-binding compounds.
Clinical studies conducted on both women and men showed that AquaCacteen was exceptionally soothing and firming. Besides it was found to be very hydrating even in rinse-off products.

Claims with AquaCacteen
• Soothes and calms irritated skin
• Hydrates the skin even in rinse-off formulation
• Protects and firms the skin
Available in an ECOCERT certified version