NICHIRIN CHEMICAL INDUSTRIES LTD.,JAPAN.
PRODUCT NAME COMPARISON CHART
CARBOXYMETHYL CELLULOSE AND CHELATES CARBOXYMETHYL CELLULOSE – CALCIUM CARMELLOSE - Ca USP/NF, JP, EP SUPER DISINTEGRANTS FOR IMMEDIATE RELEASE TABLETS NAME NS-300 ECG-505
CHEMICAL CLASS Carmellose Is Polycarboxymethylether Of Cellulose Carmellose-Calcium Is Calcium Salt Of Polycarboxymethylether Of Cellulose.
CHEMICAL
DIFFERENCE		 It Is Produced By Lowering pH Of
Na-CMC By An Acid Treatment
Only Disintegrant Having Calcium Ion As A Chelate In World.
STABILITY REPORT No Interactions Reported With API On Longer Storage. May Interact With Some Substances Having Phosphate And Sulphate Owing To Its Calcium Content On Longer Storage.
HYDRATION ABILITY It Has Lower Ability Of Hydration As Compared To Its Calcium Chelate Derivative It Has A Higher Ability Of Adsorbing Water Necessary To Cause Swelling Due To Its Chelate Structure And Calcium Content
CARBOXYMETHYL CELLULOSE CARMELLOSE
JP		 DISINTEGRATION
MECHANISM
 Due To The Property Of Electrostatic Repulsive Force, NS-300 Shows A Wicking Type Of Mechanism Due To The Calcium Ion Present, It Shows A Swelling Type Of Action In Disintegration Mechanism
MOISTURE ADSORPTION
CAPACITY		 Moisture Adsorption Is Less In NS-300 At A Relative Humidity Between 90 – 100 % On Storage Moisture Adsorption Is Higher As Compared To NS-300 At A Relative Humidity Between 90 – 100 % On Storage
WETTING TIME Lowest Wetting Time Of 3.4 Second, Which Is Lowest Than Any Other Disintegrant It Has A Wetting Time Of 64.2 Second Though Lower Than The Others Do
APPLICATION The Acidity Of NS-300 Is Useful To Keep Stability Of Drugs, Which Are Decomposed On The Alkalic Side The Calcium Chelate Of ECG-505 Is Useful In Sodium Restricted Drug Formulations Like Cardio-Vascular Drugs
APPLICATIVE PROBLEM Sticking Problem In Wet Granulaiton Can Be Avoided Using NS-300, Due To Its Wicking Mechanism Due To Imperfect Removal Of Moisture Adsorbed By Swelling During Wet Granulation, Sticking Problem May Be Encountered